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Buy Ethionamide Online

ethionamide antibiotic
Active Ingredient: Ethionamide

Ethionamide is used to treat tuberculosis (TB). Ethionamide is an antibiotic. It prevents the growth of bacteria in your body.

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This drug Ethionamide belongs to the group of antimicrobial drugs that affect mycobacteria and are used in pulmonology in the treatment of tuberculosis.

The effect of the drug is explained by the characteristics of its main active substance. The main active component is Ethionamide.

Thioamide, a derivative of isonicotinic acid, the antibacterial properties of which are close to isoniazidum.

It is less effective against Mycobacterium tuberculosis pathogens than isoniazid. However, the effect of Ethionamide can also affect such strains to which isoniazid is not active.

The property to fight mycobacteria is explained by the mechanism of action of Ethionamide, namely, its ability to block the synthesis of mycolic acid, which is part of pathogenic bacterial cells.

It is a bacteriostatic.

Composition and form of release

Main active ingredient: Ethionamide.

Auxiliary components:

  • Cellulose,
  • Starch,
  • Sodium benzoate,
  • Hydroxypropylmethylcellulose,
  • Magnesium stearate,
  • Talc,
  • Sodium starch,
  • Polyethylene glycol,
  • Titanium dioxide,
  • Talc, etc.

Produced in the form of tablets, 250 mg of Ethionamide.


This drug is used for the treatment of tuberculosis in combination therapy with other drugs, if the patient has polyresistance to isoniazid or rifampicin, as well as, possibly, to other anti-TB drugs.


The drug Ethionamide in question is contraindicated in cases where the patient has a pronounced hypersensitivity (Allergy) to the main or to one of the auxiliary components.

Also contraindicated in:

  • Diabetes;
  • Epilepsies;
  • Severe disorders of the digestive tract and liver.

With caution, it is prescribed to patients suffering from mental disorders.

In Pediatrics, it can be used from the age of 14.

Use during pregnancy and lactation

Ethionamide is contraindicated in the treatment of pregnant women.

If you need to use the drug, if a woman is lactating, then breast-feeding should be suspended for the duration of treatment.

Dosage and administration

Intended for use in pulmonology.

The drug Ethionamide is taken orally with food or after a meal, with a small amount of water.

Adults are prescribed 15-20 mg per 1 kg of body weight once a day, daily.

In order to reduce the risk of adverse reactions, therapy is started with 250 mg per day and titrated to optimally tolerated doses (for example, 250 mg per day for 1 to 2 days, followed by an increase of 250 mg twice a day for 1 to 2 days, then the dose is increased to 1 g per day in 3 to 4 doses).

The maximum daily dose is 1 g.

Children over 14 years of age take the drug in a dosage of 10 to 20 mg per 1 kg of body weight, divided into 2-3 doses.

It is also possible to take a dosage of 15 mg per 1 kg of body weight every 24 hours, which is taken as a separate daily dose.

Correction of the duration of treatment, dosages and treatment regimens is determined by the attending physician on an individual basis, depending on individual indicators of the course of the disease.


Overdose over a long period can cause damage to the digestive tract, Central and peripheral nervous system.

In case of overdose, the drug is canceled, gastric lavage is prescribed, 1-2 ml of 5% pyridoxine hydrochloride solution, nicotinamide 0.1 g 2-3 times a day.

The antidote was not detected.

Side effect of Ethionamide

Usually the drug is well tolerated. In cases of hypersensitivity, the following reactions are possible:

  • Nausea, vomiting, diarrhea;
  • Rash, dermatitis, allergic urticaria;
  • Anorexia, stomatitis;
  • Hepatitis, jaundice;
  • Reduction of body weight, hypoglycemia, exacerbation of diabetes mellitus;
  • Neuritis, neuritis weakness, insomnia, depression, psychosis;
  • Orthostatic hypotension;
  • Thrombocytopenia, purpura;
  • Hypoglycemia, hypothyroidism, gynecomastia, menstrual disorders.

Storage terms and conditions

Shelf life-3 years from the date of manufacture indicated on the package. The storage temperature should not exceed 25°C.