Benzylpenicillin, carboxypenicillins and ureidopenicillins largely lose their properties when taken orally under the action of hydrochloric acid of gastric juice, for this reason they are administered only intramuscularly. Phenoxymethylpenicillin, oxacillin and aminopenicillins are more stable in an acidic environment, and therefore can be administered orally. A very high degree of absorption in the gastrointestinal tract…
Read MoreAllergic reactions: urticaria, rash, Quincke’s edema, fever, eosinophilia, bronchospasm, anaphylactic shock (more often when using benzylpenicillin). Measures to help with the development of anaphylactic shock: ensuring the airway patency, oxygen cushion, adrenaline, prednisone. From the Central nervous system: headache, tremors, convulsions (more often in children and in patients with renal insufficiency when using carbenicillin or…
Read MoreIncreasing the resistance of microorganisms to antibiotics is a global issue for public health organizations. The increase in resistance is particularly important for Pediatrics due to the frequent use of antibiotics for the treatment of common childhood infectious diseases in outpatient settings and severe infections in hospitals. For example, in various regions of the world,…
Read MoreAllergy. It is cross-linked to all antimicrobial drugs of the penicillin group. This means that if you are once allergic to a penicillin-type antibiotic, for example, ampicillin, it is also dangerous to use any other antibiotic from the penicillin group. Some patients with an allergic reaction to cephalosporins may allergies to penicillins may also occur.…
Read MoreNatural penicillins. Diseases that are treated primarily with penicillin antibiotics include tonsillopharyngitis, scarlet fever, erysipelas, community-acquired pneumonia, meningitis, sepsis, meningococcal infections, syphilis, leptospirosis, tick-borne borreliosis, gas gangrene, and actinomycosis. There are antibiotics that need to be taken several times a day, and there are those that are taken once a month. They have a prolonged…
Read MoreThe group of antibiotics under the General name “penicillins” includes the following drugs: amoxicillin, ampicillin, ampicillin with sulbactam, benzylpenicillin, cloxacillin, coamoxylav (amoxicillin with clavualanic acid), Flucloxacillin, methicillin, oxacillin, phenoxymethylpenicillin. Cephalosporins: cefaclor, cefadroxil, cefixime, cefoperazone, Cefotaxime, cefoxitin, cefpirome, cefsulodin, ceftazidime, ceftizoxime, Ceftriaxone, cefuroxime, cephalexin, cephalothin, of cefamandol, Cefazolin, cefradine. Penicillins and cephalosporins together with the antibiotics…
Read MoreAntibiotics are substances that selectively suppress the vital activity of microorganisms. “Selective influence” refers to the activity exclusively in the relationship of microorganisms while preserving the viability of host cells and the impact not on all, but only on certain genera and types of microorganisms. For example, fusidic acid has a high activity against staphylococci,…
Read MoreSimilar to the Pasteur Institute in Paris, the vaccination Department at St. The place where A. Fleming worked existed and received funding for research through the sale of vaccines. The scientist found that during the preparation of vaccines, penicillin protects cultures from Staphylococcus. This was a small, but serious achievement, and A. Fleming widely used…
Read Moreit is toxic to experimental animals and can kill highly resistant pathogens. There were no biochemists at St. Mary’s hospital, so it was not possible to isolate penicillin in an injectable form. This work was carried out in Oxford by H. W. Flory and E. B. Cheyne only in 1938. Penicillin would have sunk into…
Read MoreWhat was going on in the laboratories of our country at that time? Did Russian scientists sit idly by? Of course, this is not the case. Many people have read V. A. Kaverin’s trilogy “Open book”, but not everyone knows that the main character, Dr. Tatyana Vlasenkova, had a prototype-Zinaida Vissarionovna ermoleva (1898-1974), an outstanding…
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