Buy Augmentin Online
Augmentin is used to treat many different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin.
Perhaps, it is difficult to find a doctor who would never subscribed to Augmentin. Therapists, pediatricians, urologists, gynecologists, ENT doctors - doctors of all specializations do not represent their practice without the antibiotic. Moreover, in many protocols for the treatment of various diseases.
And patients and physicians perceive Augmentin as the modern anti-bacterial agent. Meanwhile, the drug is on the market for decades.
The combination of amoxicillin and clavulanic acid, which became the basis of Augmentin, was developed in 1977-1978 by scientists of the British company Beecham. Later, in 1984, the pharmaceutical giant received a patent for the original Augmentin. Today, the drug continues to produce firm GlaxoSmithKline, pravopreemenik Beecham. WHO - World Health Organization - Augmentin included in the list of essential medicines.
Popularity drugs worldwide is so high that it is among the ten best-selling antibiotics. Reviews and patients and doctors about Augmentin virtually unanimous and only confirm the universal love of the drug.
Meet Closer: the Composition and Form of Augmentin Release
Amoxicillin - a semisynthetic penicillin antibiotic with a wide spectrum of action. It represents almost Ampicillin analogue differs only minor structural changes in the chemical formula. The structure includes Augmentin amoxicillin as trihydrate.
Clavulanic acid - fermentation product of Gram-positive bacteria Streptomyces clavuligerus. This substance is a member of Augmentin as the potassium salt.
Each tablet formulation is coated with a film cover, which protects the active substance from the aggressive action of hydrochloric acid environment of the stomach.
Sometimes doctors prescribing Augmentin, indicate the total dosage of antibiotic and clavulanic acid. For example, you can often find a recipe similar content: Tab. Augmentin 1000mg. It is obvious that the doctor has a mean form of the antibiotic release containing 875 mg of amoxicillin and 125 mg clavulanic acid. Both the first and the second method is the dosage instructions are equally valid.
Wealth Release Forms
The company GlaxoSmithKline has mastered the production of such a large number of different forms of Augmentin, the antibiotic can be easy to pick up a patient of any age and weight. The search for new user-friendly doses happens to this day. Thus, children's suspension Augmentin ES was incorporated relatively recently, designed for the treatment of severe infections, as well as for older children. The drug is almost an adult dosage of the active ingredients - 600mg of amoxicillin and 42.9 mg of clavulanic acid.
It should be noted that the packaging Augmentin contains precisely calculated for a full course of treatment the number of tablets. Thus, the minimum wrap contains 14 tablets of the drug and is designed for treatment of uncomplicated infections scheme. For long-term treatment is a form of release of 20 tablets Augmentin 625 mg dose and 400 mg.
When buying Augmentin online suspension, the dosage which is based on the child's weight is calculated correctly, there is no doubt that the amount of the drug to the excess will be enough for a course of treatment. Sometimes parents are surprised to notice that on the third day of antibiotic therapy in the bottle remains only a fraction of the drug. In such cases, the most likely form of release was chosen incorrectly and need to buy a large dose of the drug Augmentin.
Can I divide the pill Augmentin?
Some Augmentin tablets, in particular the dosage of 500 mg (675 mg including clavulanate) applied transverse risk. Many patients find that the risk of separation necessary for the tablet to reduce the dosage.
Of course, from the standpoint of economy it is really advantageous. Indeed, cost, for example, tablets Augmentin 250 mg much higher than half a tablet of 500 mg. But in fact the manufacturer warns that the risk of cross-applied for the selection is not a lesser dosage. Risk tablets Augmentin performs more aesthetic function. Separation of tablets is not recommended: if after film coating is destroyed and the content of a tablet can be reacted with hydrochloric acid of the stomach.
In addition, pharmacists pay attention, that the breaking of the tablets at risk in two parts to anticipate the content of the active substances formed in the halves is almost impossible. And the likelihood that both sides of the tablet will be equal in dosage, rather illusory.
So do not philosophize. Fortunately, Augmentin distinguishes wealth release forms, and every patient, regardless of age and weight can pick up the desired dosage.
Protection Amoxicillin Clavulanate or Why?
Indeed, many patients are wondering what is the function of the clavulanic acid? What the drug enters another substance?
The fact is that during use of antimicrobials many microorganisms have learned to resist the action of drugs. Sly bacteria in an effort to continue the vital functions of steel to produce an enzyme that destroys the antibiotic. Thus, preparations of penicillin and cephalosporin containing the beta-lactam ring are inactivated by penicillinase effect that some microorganisms produce.
Scientists have discovered the ability of bacteria immediately after the creation of Amoxicillin. It was soon found and "antidote", which turned out to clavulanic acid. It is structurally similar to the beta-lactam penicillins.
Clavulanic acid inactivates beta-lactamases (enzymes group, and which includes penicillinase), blocking the active sites of these enzymes. Thus, the clavulanic acid in the composition of antibacterial drugs performs protector function. It does not allow the antibiotic to destroy bacteria and thus retains its physical and chemical structure and hence the pharmacological action.
It should be noted that not all microorganisms produce penicillinase. Therefore, the net unprotected Amoxicillin until now has been used successfully for the treatment of diseases caused by susceptible bacteria.
Augmentin: Spectrum of Activity and Pharmacological Effect
By the action of Augmentin many sensitive gram-positive and gram-negative bacteria, including:
- Staphylococcus aureus, including strains producing beta-lactamase;
- Neisser, the causative agent of gonorrhea;
- E. coli, including beta-lactamase producing;
Separately, we note that the methicillin-resistant strains of Staphylococcus aureus, which cause dangerous hospital infections, sensitive to Augmentin.
The mechanism of action Amoxicillin is very simple. Blocks the synthesis of an antibiotic sensitive microorganism cell wall and thus exerts a bactericidal effect.
Pharmacological effects in Augmentin has only one active ingredient of the drug - amoxicillin. Clavulanic acid has no antibacterial action.
When to take Augmentin
The complex of Amoxicillin and Clavulanate potassium perfectly absorbed. An hour after the oral administration contained in the blood maximum concentration of antibiotic.
The rate of absorption and distribution of the main active ingredient - Amoxicillin - is the same regardless of the meal. However, potassium clavulanate dosing regimen still has value. In clinical tests it has been found that clavulanic acid are much higher absorption when taken with food than fasting.
Scientists by GlaxoSmithKline conducted a study on the pharmacokinetics of the drug. It was found that the relative bioavailability of Augmentin significantly reduced drug when administered orally at 30 and 150 minutes after breakfast with high fat content.
The study of pharmacodynamics were developed uniform guidelines for receiving the tablets and suspensions for Augmentin children. Thus, to the maximum dose of the drug reached the destination point, the medicine should be taken at the beginning of the meal.
Indications for Use: When will Augmentin?
Indications for receiving Augmentin - is an inflammatory disease that are caused by pathogens susceptible to amoxicillin. We have already mentioned that the Augmentin belongs to the drug of choice in the treatment of many infectious pathologies. Let's try to list the main indications for use of the really powerful antibiotic:
- Upper respiratory tract infection, such as bronchitis (inflammation of the bronchi), pneumonia (simultaneous inflammation of the bronchi and lungs), pneumonia (pneumonia), lung abscess (ulcers);
- Oropharyngeal infection: bacterial tonsillitis (angina), pharyngitis, stomatitis;
- ENT infections: otitis media, sinusitis;
- Skin infections: bacterial abrasions, and other diseases caused by beta-lactamase producing strains of Staphylococcus aureus, Klebsiella and E. coli;
- Infections of the genitourinary system: cystitis (inflammation of the bladder), pyelonephritis (kidney inflammation), urethritis (inflammation of the urethra - the urethra);
- Pelvic infections, including postpartum, abortion and other interventions;
- Diseases that are transmitted through sexual contact: gonorrhea, syphilis;
- Postoperative infection;
- Osteomyelitis - inflammation of bone tissue.
The use of Augmentin: Special instructions
First of all I would like to emphasize that Augmentin is the gold standard in the treatment of diseases of the oropharynx, upper and lower respiratory tract, caused mainly by gram-positive microorganisms. The spectrum of the product is so wide that it is able to cover almost all pathogens.
Unfortunately, many therapists like "cover" two, or even three antibiotics. Often vigilant doctor reinsured thus outpatient and even inpatient treatment of pneumonia. As a result, the scheme of treatment of uncomplicated pneumonia takes "high-rise view" and contains a number of antibiotics including Augmentin. It is particularly impressive is the combination of intravenous and tablet forms of various antibacterial drugs.
Patients are not even aware that a properly selected Augmentin does not require the addition of another antibiotic. Amoxicillin activity against Streptococcus pneumoniae (pneumonia main exciter) is significantly higher than that of Ampicillin and Benzylpenicillin. Therefore, in most cases of pneumonia caused by strains with intermediate susceptibility to ampicillin and benzylpenicillin, amenable to monotherapy using Augmentin.
In the treatment of infections of the urogenital tract (inflammation of the kidneys, bladder, pelvic organs) drugs of choice are still considered fluoroquinolone antibiotics. However, this group of drugs are contraindicated for use in children. Therefore, in pediatric patients with such infections Augmentin may apply.
The Correct Dosage for Children
According to the instructions on the use of Augmentin in children a dosage adjustment is dependent on the child's age.
- Infants up to three months
The children of this age urinary system is not yet fully operational, resulting in the elimination (excretion) of standard doses of Augmentin may be difficult. Therefore, the recommended dose is 30 milligrams of drug per kilogram of body weight per day. Multiplicity of reception - twice a day ie every 12 hours.
- Children older than three months
From this age, your doctor may prescribe two versions of children's suspension:
- 1. Augmentin 200 mg in 5 ml Augmentin 400 mg in 5 ml applied twice a day, every 12 hours.
- 2. Augmentin 125 mg in 5 ml Augmentin 250 mg in 5 ml applied three times a day - every 8 hours.
Most experts prefer to use a suspension with 12-hour action. It is expected that these formulations are much less likely to cause diarrhea than 8-hour suspension Augmentin.
However, it should be borne in mind that the Augmentin suspension 200 mg and 400 mg of the composition contain aspartame, so they are banned for use in patients suffering from phenylketonuria.
Let's try to figure out how to calculate the dose of Augmentin children.
The instructions for use indicate that:
- 12-hour children's Augmentin suspension is dosed based on the rate of 45 mg / kg body weight for severe infections and 25 mg / kg - under less severe;
- 8-hour suspension Augmentin designed to 40mg / kg in severe and 20 mg / kg - in mild cases.
The term "severe infection" specialists mean otitis media, lower respiratory tract infections (pneumonia), sinusitis and disorders with severe intoxication symptoms and bright.
Here is an example. If the baby weighs 8 kg, the average severity of bronchitis he needs Augmentin 200 mg per day, divided into two doses. Based on the fact that 5 ml of the finished suspension contains 200 mg of the antibiotic, the child must receive 2.5 ml of the drug every 12 hours.
- Children weighing 40 kg or higher
Children over age category Augmentin is dosed according to the adult recommendations.
Finally, we describe the standard dose Augmentin would like to stress the importance of a competent physician's advice. Despite the sometimes detailed description of the calculation of the children's dose instructions or articles on Augmentin, it is best not to engage in independent action with the selection of doses, and give the reins of a specialist. Only a doctor can properly evaluate the severity of your child's disease and choose the right dose of the antibiotic. Keep this in mind and do not overestimate your capabilities. Also, always ask about the instruction offered directly to the drug.
Augmentin: Adult Dosage
With dosages for adults the situation is much simpler. However, here we must take into account the severity of the disease.
As for the use of Augmentin tablets instructions described that includes a standard adult dose of 500 mg every 12 hours or 250 mg - every 8 hours.
For treatment of more severe disease and lower respiratory tract infections Augmentin dose increased to 875 mg every 12 hours or 500 mg - every 8 hours.
Adults who have difficulty swallowing whole tablets, may take a suspension of 125 mg or 250 mg instead of Augmentin 500 mg. Tablets 875 mg dose in such cases replace Augmentin suspension containing 200 or 400 mg of the antibiotic.
Allergy to Penicillins: Do not Miss!
The main contraindication to receiving Augmentin - an allergic reaction to penicillin antibiotics.
During postmarketing studies Augmentin, which have been going on for about 30 years, was recorded quite a number of severe cases of individual hypersensitivity to the drug. They were shown an anaphylactic reaction to a Penicillin antibiotic Amoxicillin.
I would like to reassure patients that still do not know anything about allergies. All cases Augmentin individual reactions occurred in patients with an allergy to penicillin or other drugs allergens in an amount of more than two.
Also, note the cross-sensitivity of penicillin and cephalosporin antibiotics. If the patient has a history of allergies, for example, on ceftriaxone, the probability of reaction to Augmentin is very high. In such situations, the risk just is not worth - a much easier and safer to choose an antibiotic from a different group.
Contraindications to Augmentin Treatment
Let's try to list the major contraindications to receiving Augmentin:
- An allergic reaction to penicillin or cephalosporin antibiotics;
- Abnormal liver function in the treatment of Augmentin in history (ie, the previous reception of a preparation);
- Idiosyncrasy Augmentin components;
- Infectious mononucleosis. Wrong assignment of penicillin in this disease (note viral disease) leads to the appearance of the characteristic rash.
During pregnancy and lactation Augmentin allowed conditionally. This rather vague phrase means only that a sufficient number of clinical studies investigating the effect of the drug on the course of pregnancy, was not carried out. The drug, without a doubt, crosses the placental barrier and into breast milk.
However, due to the extremely low toxicity and broad-spectrum antibiotic Augmentin exactly this is the drug of choice in the treatment of many infectious diseases in pregnant women, and lactating women.
Augmentin Side Effect: What can we expect?
Let's try to list the main adverse events that may occur during or after a course of treatment Augmentin:
- Bowel violation
The so-called "dysbiosis", which we are afraid of doctors and pharmacists, sometimes really develops after antibiotic treatment. In medicine, this phenomenon is called pseudomembranous colitis. The reason for this complication is that treatment with antibiotics can change the normal intestinal flora. This opportunistic microorganisms may begin to proliferate and produce toxins.
Studies show that the main cause of colitis associated with antibiotic treatment, a toxin, which is produced by Clostridium. Diarrhea, which is often the only symptom complications can have varying degrees of severity from mild to severe to most cases. The latter is most often recorded in patients suffering from immunodeficiency.
On average, antibiotic-associated diarrhea is observed in 9% of patients receiving Augmentin.
- Abnormal liver function
The negative effect of Augmentin in the liver and biliary tract is registered in less than 5% of cases. At the same time the majority of patients the function of the hepatobiliary system repairs itself after the abolition of the antibiotic.
Serious violations, which are shown lesions of the liver tissue, have been reported in rare cases. For example, GlaxoSmithKline company confirms the information about one death from hepatotoxic action Augmentin. However, we hasten to reassure patients who took his heart. The probability of such a reaction is close to zero - it is possible only in one of their 4 000 000 patients!
However, in order to avoid complications during long-term treatment augmentin experts recommend periodically monitor liver function.
- llergic dermatitis
The probability of occurrence of dermatological lesions on the background of Augmentin treatment is 3%. Generally, these symptoms did not require discontinuation of antibiotic and tested at the end of treatment.
- Nausea and vomiting
Some patients are fixed dyspepsia associated with taking Augmentin: nausea (3% of patients) and vomiting (1%). To reduce the risk of these side effects, you need to follow the rules of admission Augmentin and take the medicine at the beginning of the meal.